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To confirm these results, the authors proposed to engineer the CHO host cell line to eliminate the endogenous expression of LPLA2 and to repeat the formulation experiments to determine whether they are stabilised, i.e., reduced polysorbate hydrolysis, using the LPLA2 knockout approach (Hall et al., 2016)

Jan 2012;33(1):199.e1-12

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The myometrium, the predominant layer, contains longitudinal and circular smooth muscle fibers and is responsible for uterine contractility, essential for menstruation, implantation, and parturition (Wray and Prendergast, 2019)